1. [CERAMIDAS] tsuchiya, y., ban, m., kishi, m., ono, t., masaki, h. (2020). Oral intake of ceramide-containing acetic acid bacteria significantly improves stratum corneum hydration in dry skin without causing harmful effects.
2. [CERAMIDAS] leo, t., tan, e., amini, f., rehman, n., ng, e. s. c., tan, c. k. (2022). Rice ceramides supplementation effectively improves skin barrier function, reduces wrinkle severity, and reduces pigmentation, with older age being more responsive.
3. [CERAMIDAS] kimata, h. (2006). Oral intake of konjac ceramide improves skin symptoms and reduces allergic responses in children with atopic dermatitis, promoting a th1 cytokine response.
4. [CERAMIDAS] oda, t., tachimoto, h., kishi, m., kaga, t., ichihashi, m. (2010). Oral intake of ceramide-containing acetic acid bacteria can help maintain skin barrier function in healthy adults with dry skin.
5. [CERAMIDAS] bizot, v., cestone, e., michelotti, a., nobile, v. (2017). Oral supplementation with wheat glucosylceramides and digalactosyldiglycerides significantly improves skin hydration, elasticity, and smoothness, while decreasing trans epidermal water loss, roughness, and wrinkledness.
6. [CERAMIDAS] venkataramana, s. h., puttaswamy, n., kodimule, s. (2020). Oral intake of glycosyl ceramides from amorphophallus konjac tubers significantly improves skin health, reducing dryness, hyperpigmentation, redness, itching, and oilyness without causing adverse events or toxic changes.
7. [CERAMIDAS] shimoda, h., terazawa, s., hitoe, s., tanaka, j., nakamura, s., matsuda, h., yoshikawa, m. (2012). Oral dosing of rice-derived glucosylceramide can compensate for epidermal loss of ceramides and improve epidermal water loss and barrier function in both mice and human epidermal equivalents.
8. [CERAMIDAS] mizutani, y., mitsutake, s., tsuji, k., kihara, a., igarashi, y. (2009). Ceramides play a crucial role in maintaining skin health and barrier function, crucial for understanding skin conditions.
9. [ÁCIDO HIALURÓNICO] göllner, i., voss, w., von hehn, u., kammerer, s. (2017). Oral hyaluronic acid supplements can improve skin elasticity, hydration, and reduce skin roughness and wrinkle depths without causing side effects.
10. [ÁCIDO HIALURÓNICO] hor, k., lew, l., choi, s. b., liong, m. (2014). Ultrasonic treatment significantly enhances the production of hyaluronic acid by lactobacilli, potentially benefiting skin health.
11. [ÁCIDO HIALURÓNICO] oe, m., mitsugi, k., odanaka, w., yoshida, h., matsuoka, r., seino, s., kanemitsu, t., masuda, y. (2014). Orally administered hyaluronic acid can migrate into the skin of rats, but most of it is excreted in expired air or urine.
12. [ÁCIDO HIALURÓNICO] aguirre, a., gil-quintana, e., fenaux, m., erdozain, s., sarria, i. (2017). Oral supplementation with ovoderm significantly improves skin elasticity and reduces skin pigmentation, improving the appearance of aged skin.
13. [ÁCIDO HIALURÓNICO] kang, m.-c., yumnam, s., kim, s. (2018). Oral collagen peptide intake can improve skin hydration and reduce wrinkle formation after UVB irradiation by increasing hyaluronic acid levels.
14. [ALOE VERA] misawa, e., miyuki tanaka, f. abe, k. yamauchi, marie saito, k. nabeshima (2019). Aloe sterols, found in aloe vera gel, significantly improve skin barrier function, moisture, elasticity, and dermal collagen content, making them a useful functional food material for maintaining and promoting skin health.
15. [ALOE VERA] tanaka, m., misawa, e., yamauchi, k., abe, f., ishizaki, c. (2015). Daily oral aloe sterol-containing AVGP significantly reduced facial wrinkles in women aged 40 years, and stimulated collagen and hyaluronic acid production by human dermal fibroblasts.
16. [ALOE VERA] tanaka, m., yamamoto, y., misawa, e., nabeshima, k., saito, m., yamauchi, k., abe, f., furukawa, f. (2017). Aloe sterol supplementation contributes to maintaining healthy skin by improving skin elasticity, hydration, and collagen score.
17. [ALOE VERA] k. na, enkhmaa lkhagva-yondon, minha kim, yu-ree lim, eunju shin, c. lee, myung-shin jeon (2019). Oral administration of aloe polysaccharide gel improves atopic dermatitis by restoring tight junction gene expression and suppressing inflammatory cytokines in skin.
18. [ALOE VERA] marie saito, miyuki tanaka, e. misawa, r. yao, k. nabeshima, k. yamauchi, f. abe, yuki yamamoto, f. furukawa (2016). Oral aloe vera gel powder can prevent skin photoaging by suppressing UVB-induced overexpression of MMPs and loss of hyaluronic acid in hairless mice.
19. [ALOE VERA] n. kathuria, neelam gupta, manisha, r. prasad, nikita (2010). Aloe vera gel is effective in treating oral conditions, improving oral hygiene, and promoting cell growth and detoxification.
20. [ALOE VERA] m. hęś, k. dziedzic, d. górecka, a. jędrusek-golińska, e. gujska (2019). Aloe vera has anti-inflammatory, lipid and carbohydrate metabolism support, and antioxidant properties, making it a valuable natural source for maintaining health and maintaining nutritional value in cosmetic, pharmaceutical, and food industries.
21. [ALOE VERA] meitha meitha, widurini widurini (2003). Fresh aloe vera can effectively cure oral mucosa inflammation caused by hydrogen peroxide 10% better than distillate aloe vera.
22. [MELATONINA PIEL] sagan, d., stępniak, j., gesing, a., lewiński, a., karbownik-lewińska, m. (2017). Melatonin oral treatment reduces oxidative damage to membrane lipids and improves skin biophysical characteristics in former-smokers.
23. [MELATONINA PIEL] slominski, a., hardeland, r., żmijewski, m., slominski, r., reiter, r., paus, r. (2018). Melatonin shows promise in managing oxidative-damaged skin conditions, promoting skin cancer prevention, and aiding in skin repair from environmental damage.
24. [MELATONINA PIEL] snell, r. (1965). Prolonged administration of large doses of melatonin does not affect melanogenesis in the skin of guinea pigs, suggesting it has no effect on human pigmentation.
25. [MELATONINA PIEL] kumar, c. a., das, u. (2000). Melatonin can reduce skin cancer papillomas and prevent DNA binding, suggesting its potential as an endogenous anti-mutagenic and oncostatic agent.
26. [MELATONINA PIEL] smith, i., mullen, p., silman, r., snedden, w., wilson, b. (1976). Melatonin is present in human plasma and cerebrospinal fluid, providing evidence for its existence and potential endocrine role.
27. [MELATONINA PIEL] fischer, t., wigger‐alberti, w., elsner, p. (1999). Melatonin plays a role in regulating various physiological processes, aging, and immune defense, and may play a role in treating various dermatological conditions and inhibiting UV-induced erythema.
28. [MELATONINA SUEÑO] poza, j., pujol, m., ortega-albás, j., romero, o. (2018). Melatonin may be a promising treatment for insomnia, but more scientific evidence is needed to confirm its effectiveness and optimal dose ranges and preparations.
29. [MELATONINA SUEÑO] lee, e. k., poon, p., yu, chun-pong, lee, v., chung, v., wong, s. (2022). Oral melatonin supplementation may reduce asleep systolic blood pressure and improve sleep quality, but more high-quality randomized controlled trials are needed to confirm these findings.
30. [MELATONINA SUEÑO] phillips, l., appleton, r. (2004). Melatonin may help reduce time to sleep onset in children with neurodevelopmental disabilities, but has no significant effect on total sleep time, night-time awakenings, or parental opinions.
31. [MELATONINA SUEÑO] arendt, j. (2000). Melatonin is a useful sleep therapy for certain conditions, but its long-term safety and effectiveness remain inconclusive.
32. [MELATONINA SUEÑO] waldhauser, f., saletu, b., trinchard-lugan, i. (2005). A single dose of melatonin can accelerate sleep initiation, improve sleep maintenance, and alter sleep architecture, with good tolerance and no hangover problems the following morning.
33. [MELATONINA SUEÑO] wesensten, n., balkin, t., reichardt, r. m., kautz, m., saviolakis, g., belenky, g. (2005). Melatonin 5 mg alone improved daytime sleep without impairing memory and vigilance, suggesting potential advantages in the operational environment.
34. [MELATONINA SUEÑO] jan, j., o'donnell, m. (1996). Melatonin is a safe, inexpensive, and effective treatment for chronic sleep disorders in children with disabilities, benefiting over 80% of patients.
35. [MELATONINA SUEÑO] beresford, b., mcdaid, c., parker, a., scantlebury, a., spiers, g., fairhurst, c., hewitt, c., wright, k., dawson, v., elphick, h., thomas, m. (2018). Melatonin may increase total sleep time in children with neurodisabilities, but its effectiveness and safety remain unclear due to high statistical heterogeneity and poor reporting.
36. [MELATONINA SUEÑO] tufteland, m., lenon, a., carlile, s., kingsley, k. (2022). Melatonin supplementation may affect oral keratinocytes and gingival fibroblasts, potentially improving sleep duration and quality, but no significant changes in cellular viability were observed.
37. [MELATONINA SUEÑO] foley, h., steel, a. (2019). Oral melatonin supplementation has a generally favorable safety profile, with minor, short-lived adverse events affecting fatigue, mood, and psychomotor and neurocognitive performance.
38. [MELATONINA SUEÑO] dagan, y., yovel, i., hallis, d., eisenstein, m., raichik, i. (1998). Melatonin treatment is a simple and effective long-term treatment for delayed sleep phase syndrome, with 96.7% of patients reporting it as helpful and no side effects.
39. [ASHWAGANDHA PIEL] sikandan, a., shinomiya, t., nagahara, y. (2018). Ashwagandha root extract (ASH-WEX) exhibits anti-inflammatory effects on skin by suppressing NF-B and MAPK pathways and modulating cytokine expression, suggesting potential protection against skin inflammation.
40. [ASHWAGANDHA PIEL] balkrishna, a., nain, p., chauhan, a., sharma, n., gupta, a., ranjan, r., varshney, a. (2020). Fatty acids from Withania somnifera seeds have strong anti-inflammatory properties and show remarkable therapeutic potential in treating psoriasis-like skin etiologies.
41. [ASHWAGANDHA ESTRÉS, SUEÑO] o'connor, j., lindsay, k., baker, c., kirby, j., hutchins, a., harris, m. (2022). Ashwagandha can effectively manage stress and improve sleep quality in college students in as little as 30 days, with lower food cravings observed over time.
42. [ASHWAGANDHA ESTRÉS, SUEÑO] manchanda, s., mishra, r., singh, r., kaur, t., kaur, g. (2017). Ashwagandha leaf extract shows potential as a neuroprotective agent in sleep-deprived rats, improving behavioral performance and reducing cellular stress and apoptosis in the brain.
43. [ASHWAGANDHA ESTRÉS, SUEÑO] yang, l., chen, x., gao, y. (2022). Ashwagandha supplements with higher levels of withanolides are more effective in treating insomnia and improving sleep quality, while unstandardized ashwagandha may only increase energy levels.
44. [ASHWAGANDHA ESTRÉS, SUEÑO] kumar, v., dey, a., chatterjee, s. (2017). Ashwagandha (Withania somnifera) may be used for prevention and treatment of diabetes and related metabolic disorders, offering potential for sustainable and reproducible health benefits in patients.
45. [ASHWAGANDHA ESTRÉS, SUEÑO] kumar, a., kulkarni, s. k. (2005). Ashwagandha and BR-16A can promote sleep and reduce insomnia doses when combined with GABAergic drugs like triazolam and alprazolam.
46. [ASHWAGANDHA ESTRÉS, SUEÑO] baker, c., kirby, j., o'connor, j., lindsay, k., hutchins, a., harris, m. (2022). Ashwagandha supplementation for college students improved their perceived well-being by supporting sustained energy, mental clarity, and enhanced sleep quality.
47. [ASHWAGANDHA ESTRÉS, SUEÑO] salve, j., pate, s., debnath, k., langade, d. (2019). Ashwagandha root extract significantly reduces stress and anxiety in healthy adults, with a dose-response relationship observed in this study.
48. [ASHWAGANDHA ESTRÉS, SUEÑO] gopukumar, k., thanawala, s., somepalli, v., rao, t. s. s., thamatam, v. b., chauhan, s. (2021). Ashwagandha root extract significantly improves recall memory and reduces stress levels in stressed adults, with no significant adverse effects observed.
49. [ASHWAGANDHA ESTRÉS, SUEÑO] langade, d., thakare, v., kanchi, s., kelgane, s. b. (2020). Ashwagandha root extract significantly improves sleep parameters in both healthy and insomnia patients, with more significant improvements in insomnia patients.
50. [ASHWAGANDHA ESTRÉS, SUEÑO] upadhyay, a., bansal, c., umesh, s. (2020). Ashwagandha root powder combined with brimhana nasya with ksheera bala taila significantly improves sleep quality and efficiency in elderly patients with primary insomnia.
51. [ASHWAGANDHA ESTRÉS, SUEÑO] kelgane, s. b., salve, j., sampara, p., debnath, k. (2020). Ashwagandha root extract significantly improves general well-being and sleep quality in elderly individuals, with no significant adverse events observed.
52. [ASHWAGANDHA ESTRÉS, SUEÑO] murthy, s. v., fathima, s. n., mote, r. (2022). Ashwagandha extract improves sleep quality by modulating GABA/histamine receptors and EEG slow-wave patterns, reducing sleep onset time and increasing sleep duration in experimental models.
53. [ASHWAGANDHA ESTRÉS, SUEÑO] langade, d., kanchi, s., salve, j., debnath, k., ambegaokar, d. (2019). Ashwagandha root extract is an effective and safe alternative treatment for insomnia and anxiety, with significant improvements in sleep onset latency and sleep efficiency compared to placebo.
54. [ASHWAGANDHA ESTRÉS, SUEÑO] cheah, k. l., norhayati, m. n., yaacob, l. h., rahman, r. a. (2021). Ashwagandha extract has a small but significant effect on improving sleep in adults, with more pronounced effects in insomnia patients.
55. [ASHWAGANDHA ESTRÉS, SUEÑO] kaushik, m. k., kaul, s., wadhwa, r., yanagisawa, m., urade, y. (2017). Triethylene glycol is an active sleep-inducing component of ashwagandha leaves, potentially useful for insomnia therapy.
56. [ASHWAGANDHA ESTRÉS, SUEÑO] mazur, k., lewicki, m., mazur, d., smoleń, a. (2021). Ashwagandha root extract shows efficacy and safety in treating insomnia, anxiety, and reducing stress, but further research is needed to confirm its role in these conditions.
57. [ASHWAGANDHA ESTRÉS, SUEÑO] deshpande, a., irani, n., balakrishnan, r. (2018). Ashwagandha extract may improve nonrestorative sleep and reduce anxiety and stress, potentially benefiting individuals with chronic inflammation-related sleep disorders.
58. [ASHWAGANDHA ESTRÉS, SUEÑO] jedruszczak, p., zdun, s., walczak, k., wesołowska, z., gaweł, w. (2023). Ashwagandha supplementation improves sleep quality and reduces oxidative stress, potentially benefiting both insomniacs and healthy individuals.

COMPLEMENTO ALIMENTICIO A BASE DE ASHWAGANDHA, ÁCIDO HIALURÓNICO, CERAMIDAS, ALOE VERA Y MELATONINA

ADVERTENCIAS Y RESTRICCIONES DE USO: producto para uso en adultos. los complementos alimenticios no sustituyen una dieta variada y equilibrada ni un estilo de vida saludable. este producto no está diseñado para diagnosticar, tratar o prevenir ninguna enfermedad. no superar la dosis diaria expresamente recomendada. mantener fuera del alcance de los niños más pequeños. estos
complementos alimenticios no deben ser consumidos por lactantes, niños ni adolescentes menores de 14 años.

CONDICIONES DE CONSERVACIÓN: conservar bien cerrado en un lugar fresco y seco.